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This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that. 2 days ago This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a. The glucokinase regulatory protein (GKRP) also known as glucokinase ( hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP.
Glucokinase (GCK; ) in the liver and pancreatic beta cells is subject to inhibition by a regulatory protein, GCKR. The inhibitory effect of GCKR depends on. Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with. View mouse Gckr Chr with: phenotypes, sequences, polymorphisms, proteins, references, function, expression.
Summary of GCKR () expression in human tissue. Selective nuclear expression in hepatocytes and subset of cells in stomach mucosa. GCKR Antibody (N) is a well characterized goat polyclonal recommended for detecting GCKR of mouse, rat and human origin by WB, IP, IF and ELISA. GCKR Polyclonal Antibody from Invitrogen for Western Blot applications. This antibody reacts with Mouse, Rat samples. Supplied as ug purified antibody. GCKR Polyclonal Antibody from Invitrogen for Western Blot and Immunohistochemistry (Paraffin) applications. This antibody reacts with Human, Mouse samples. Reduction of GCKR expression inhibits Wnt3a-induced phosphorylation of GSK3beta at serine 9 and decreases the accumulation of cytosolic beta-catenin [ 4].
31 Jan Background Variants in gene encoding glucokinase regulator protein (GCKR) were found to have converse effects on triglycerides and glucose. CONCLUSIONS— GCKR-L carriers are protected against type 2 diabetes despite higher triglyceride levels and risk of dyslipidemia, which suggests a. Gene: GCKR ENSG Description. glucokinase regulator [Source: HGNC Symbol;Acc:HGNC]. Location. Chromosome 2. 9 Feb [PMID ] rs, a SNP in the GCKR gene encoding the glucokinase regulatory protein, contributes to the risk of type-2 diabetes.